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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

✍ Scribed by D Riendeau; M D Percival; S Boyce; C Brideau; S Charleson; W Cromlish; D Ethier; J Evans; J -P Falgueyret; A W Ford-Hutchinson; R Gordon; G Greig; M Gresser; J Guay; S Kargman; S Léger; J A Mancini; G O'Neill; M Ouellet; I W Rodger; M Thérien; Z Wang; J K Webb; E Wong; L Xu; R N Young; R Zamboni; P Prasit; C -C Chan

Book ID
110002869
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
479 KB
Volume
121
Category
Article
ISSN
0007-1188

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✍ W.C. Black; C. Bayly; M. Belley; C.-C. Chan; S. Charleson; D. Denis; J.Y. Gauthi 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 307 KB

A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidence of GI toxicity, even