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Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopaminergic system

✍ Scribed by Paola Devoto; Maria Collu; Anna Lisa Muntoni; Marco Pistis; Gino Serra; Gian Luigi Gessa; Marco Diana

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
288 KB
Volume
20
Category
Article
ISSN
0887-4476

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✦ Synopsis

Systemic administration of the putative selective D, receptor agonist 7-hydroxy-2-(N,N-di-n-propylamino)tetralin (7-OH-DPAT) consistently decreased extracellular dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens and dopaminergic neuronal activity in the ventral tegmental area. 7-OH-DPAT inhibited dopamine release in the nucleus accumbens also when locally perfused through the dialysis probe. The results suggest the possibility that stimulation of dopamine D, receptors with 7-OH-DPAT mimic biochemical and electrophysiological actions previously ascribed to D, autoreceptor stimulation; however the lack of selective D, antagonist precludes any firm conclusion in this sense. o 1995 Wiley-Liss, Inc.

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