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Biochemical and density assessment of the new bone in late remodeling after callus distraction

✍ Scribed by Johan Lammens; Jeroen Aerssens; Jos Nijs; Luc Mokassa; Jan Dequeker; Roger Bouillon; Guy Fabry

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
685 KB
Volume
15
Category
Article
ISSN
0736-0266

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✦ Synopsis

Abstract

Biochemical changes in a canine bone‐lengthening model were characterized 5 months after surgery. The mineral content and the total amount of EDTA‐extractable noncollagenous proteins, insulin‐like growth factor‐I, and osteocalcin were determined for the lengthened callus, and a gradient density fractionation analysis of bone powder particles was performed. The results were compared with two other areas of the lengthened tibia and one region of the contralateral tibia. The mineral and osteocalcin contents showed significant decreases, whereas the hydroxyproline concentration was significantly increased. Neither the insulinlike growth factor‐I content nor the concentration of EDTA‐extractable proteins was significantly different in any of the examined regions.

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## Abstract Distraction osteogenesis is used both for leg lengthening and for bone transportation in the treatment of fractures and non‐unions. The main problem with this method is that the time until full recovery may be up to a year, partly because of the time needed for the new formed bone to co