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Biocatalytic oxidation of 1,4-diols andγ-lactols intoγ-lactones: application to chemoenzymatic synthesis of drospirenone

✍ Scribed by Romano, Diego; Contente, Martina; Granato, Tiziana; Remelli, William; Zambelli, Paolo; Molinari, Francesco


Book ID
120450045
Publisher
Springer Vienna
Year
2013
Tongue
English
Weight
205 KB
Volume
144
Category
Article
ISSN
0026-9247

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Diastereoselective synthesis of 2,3,4-tr
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The acid-catalyzed ring opening of the title epoxide 1 takes place at the C-l atom with retention of configuration at C-2 to form 2,3-cis-2-hydroxy-substituted y-lactol deriva= tives 3 In basic media, nucleophiles attack the C-Atom with inversion of configuration yielding 2,3-trans-lactols 5. Oxidat