A series of novel (R)-5-phenylfuran-2-yl cyanomethyl butanoates were prepared by Pseudomonas cepacia lipasecatalysed dynamic kinetic resolution in toluene. The method exploits a basic resin both for the racemization and formation of phenylfuran-based cyanohydrins and for the decomposition of acetone
✦ LIBER ✦
Biocatalytic enantioselective preparation of phenothiazine-based cyanohydrin acetates: kinetic and dynamic kinetic resolution
✍ Scribed by Csaba Paizs; Petri Tähtinen; Monica Toşa; Cornelia Majdik; Florin-Dan Irimie; Liisa T. Kanerva
- Book ID
- 108282685
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- French
- Weight
- 212 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0040-4020
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Kinetic resolution of racemic l-cyano-l-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia mist IAM 4682, which -hydrolyzed selectively the (RI-enantianer, leaving behind the (S)-enantianer intact. The chiral l-cyano-lmethyl-5-hexenyl acetate thus obtained was converted to