An improved process of separation of R-
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Erika Vรกrkonyi-Schlovicskรณ; Kรกlmรกn Takรกcs; Istvรกn Hermecz
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Article
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1997
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Journal of Heterocyclic Chemistry
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English
โ 169 KB
## Abstract Diastereomeric timolol tartrates 4 are obtained in a oneโpot synthesis from the racemic base 2 and optically active __O,O__โdiacetylโ or __O,O__โdibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4