Biocatalyst-mediated expansion of ring D in azadirachtin, a potent insect antifeedant from Azadirachta indica

✍ Scribed by K.M Madyastha; K Venkatakrishnan

• Book ID: 104261775
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 246 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00992-2

✦ Synopsis

A microorganism identified as Nocardia Sp.capable of converting azadirachtin 1 into three metabolites, viz. 3deaeetylazadirachtin 2, 1-detigloyi-3-deacetyl-azadirachtin-l-ene-3-one 3 and l-detigloyl-3-deacetyl-11,19deoxa-12,19-oxa-ll-oxo-~dirachtin-l-ene-3-one 4, has been isolated. This is the first report on the funetionalization of azadirachtin using biocatalysts wherein two novel, hitherto unknown metabolites have been isolated and characterized.