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Biocatalysis for Pharmaceuticals—Status and Prospects for a Key Technology

✍ Scribed by Barry C. Buckland; David K. Robinson; Michel Chartrain

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
245 KB
Volume
2
Category
Article
ISSN
1096-7176

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✦ Synopsis

In reviewing how biocatalysis can be applied to improve chiral synthesis for pharmaceuticals it becomes clear that there will be many opportunities using a simple enzyme system but that many of the more useful applications will require the whole cell because of the requirement for cofactors. An assessment is made of the opportunities to apply metabolic engineering to construct de novo metabolic pathways for the biosynthesis of useful advanced intermediates and a conceptual example is provided for the biosynthesis of cis-aminoindanol. We predict that in the future novel pathways will be assembled for a one-step biosynthesis of many semisynthetic natural products.

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