Bioavailability of L-DOPA from HP-200—a Formulation of Seed Powder of Mucuna pruriens (Bak): a Pharmacokinetic and Pharmacodynamic Study
✍ Scribed by S. S. Mahajani; V. J. Doshi; K. M. Parikh; B. V. Manyam
- Book ID
- 101286401
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 279 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
HP-200, a formulation made from the seed powder of Mucuna pruriens, contains among other constituents, about 4% L-DOPA. After five normal human volunteers were each given a single oral dose of 30 g of HP-200, plasma samples were obtained at 0,20,40,60,90, 120, 180,240 and 360 min for assay of L-DOPA by HPLC technique using electrochemical detection. The supine systolic and diastolic blood pressures were recorded at each sampling time. The results indicate that on oral administration, L-DOPA was absorbed from HP-200 with plasma peak levels (C,=1.56+0.163 pg/mL) achieved at Tm,,=83k16.09 min. The plasma half life was 102k2 rnin and the auc was determined as 6.508 f0.421 pg/h/mL. The pharmacokinetic profile of HP-200 exhibited characteristics similar to formulations of synthetic L-DOPA, except for the lack of a sharp peak. HP-200, a new herbal formulation, appears to be suitable for the treatment of Parkinson's disease.