Bioavailability of Four Different Pharmaceutical Preparations of Carbamazepine
✍ Scribed by Pynnönen, S. ;Mäntylä, R. ;Iisalo, E.
- Book ID
- 114799542
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Weight
- 283 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0001-6683
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In order to compare the multiple-dose bioavailability of carbamazepine (CBZ) from 2 slow-release preparations, Neurotol slow and Tegretol Retard, a single-blind, randomized, cross-over study was carried out. 21 adult patients with epilepsy were enrolled in the study. At the end of both 2-week treatm
The relative bioavailability of four different carbamazepine products, showing large differences in in vitro dissolution profiles, was studied in healthy volunteers to correlate the occurrence of side effects with a measure of the rate of absorption in vivo for bioequivalence testing. Two of the thr