Bioavailability of a commercial sustained-release quinidine tablet compared to oral quinidine solution

✍ Scribed by William T. Sawyer; Charles C. Pulliam; Albert Mattocks; James Foster; B. Wesley Hadzija; Harold M. Rosenthal

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 458 KB
• Volume: 3
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510030403

✦ Synopsis

Abstract

The bioavailability of quinidine sulfate after oral administration of a commercial sustained‐release quinidine tablet was compared with that of oral quinidine sulfate solution in 18 normal subjects. Three hundred milligrammes of each product was administered to each subject in standard cross‐over fashion on separate occasions, with plasma quinidine levels measured for 46 h after each dose. Although peak plasma quinidine levels were lower, and occurred later, after tablet administration than after solution, analysis of the area under the plasma quinidine level‐time curve (AUC) values for each product indicated that the products were equivalent, in terms of the extent of absorption, with the mean AUC (0–46h) value for the tablet, 8744.4 ng × h ml^−1^, comparable to that of the solution, 9145.9 ng × h ml^−1^.