Bioavailability in human volunteers of three intramuscular formulations of cefonicid: A long-acting cephalosporin

✍ Scribed by W. Brumfitt; J. M. T. Hamilton-Miller; Deirdre Grady; I. James; Colette Price

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 336 KB
• Volume: 9
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bod.2510090303

✦ Synopsis

Three different intramuscular formulations of cefonicid (a new long acting cephalosporin) have been tested for bioavailability in 12 healthy volunteers, using a triple crossover design. No significant differences were detectable between the bioequivalence of the three formulations in terms of area-under-curve and 24-h urinary excretion. However, one of the formulations (A) was absorbed significantly more rapidly from the site of injection, causing higher serum levels for up to 1.5 h after administration. A significantly greater urinary excretion was also found up to 8 h after admininstration of formulation A. All three formulations were well tolerated, and no side-effects or significant changes in laboratory tests were observed.