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Bioanalytical considerations for compounds containing free sulfhydryl groups

✍ Scribed by Nuggehally R. Srinivas; Rao N. V. S. Mamidi

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
98 KB
Volume
17
Category
Article
ISSN
0269-3879

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✦ Synopsis

Thiol-containing compounds pose bioanalytical challenge in several dimensions due to extreme reactivity of the sulfhydryl group. The development of robust bioanalytical methodology for thiol groups should address the aspects of adequate stabilization in the biological matrix and selectivity considerations. In this context, availability of plethora of thiol reagents provides ample opportunity to achieve the above goals. However, several considerations need to be factored into the decision-making of a suitable scheme for the thiol drugs under investigation. This review provides some critical insights to many such considerations that may be vital for development and validation of methods for thiol-containing drugs.

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