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Bioaffinitive and Nanosized Polymeric Micelles Based on a Reactive Block Copolymer

✍ Scribed by Yong-Chen Hu; Cai-Yuan Pan

Book ID
102498215
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
197 KB
Volume
26
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

Summary: Bio‐affinitive, nanosized polymeric micelles with glucosamine in their corona have a specific interaction with Concanavalin A. They are prepared by a substitution reaction of p‐nitrophenol groups in the poly(p‐nitrophenyl acrylate) (PNPA) corona of stable micelles with glucosamine. The nanosized, stable, and reactive micelles are formed by self‐assembly of the diblock copolymer, poly(p‐nitrophenyl acrylate)‐block‐polystyrene (PNPA‐b‐PSt) in nitromethane, followed by a shell cross‐linking reaction. This method may be useful in the preparation of targeted drugs.

A schematic of the formation of stable glucosamine‐carrying micelles from the diblock copolymer, PNPA‐b‐PSt.

magnified imageA schematic of the formation of stable glucosamine‐carrying micelles from the diblock copolymer, PNPA‐b‐PSt.

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## Abstract A biodegradable amphiphilic block copolymer, PEG__‐b‐__P(LA__‐co‐__MAC), was used to prepare spherical micelles consisting of a hydrophobic P(LA__‐co‐__MAC) core and a hydrophilic PEG shell. To improve their stability, the micelles were crosslinked by radical polymerization of the doubl