Bioadhesive Properties of a Polyaminoacidic Hydrogel: Evaluation by ATR FT-IR Spectroscopy

✍ Scribed by Filippo Saiano; Giovanna Pitarresi; Delia Mandracchia; Gaetano Giammona

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 184 KB
• Volume: 5
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200400223

✦ Synopsis

Abstract

Summary: The bioadhesive properties of a novel chemical hydrogel based on a polymer of protein‐like structure, have been investigated by using ATR FT‐IR spectroscopy. In particular, the copolymer PHG obtained by partial derivatization of PHEA with GMA was chemically crosslinked by UV irradiation at 313 nm. Crosslinked PHG was treated with water to obtain a swelled sample, named PHG‐UV gel, that was brought into contact with a phosphate buffer/citric acid solution at pH 7.0 in the absence or in the presence of mucin at various concentrations (0.01, 0.1 and 1 wt.‐%). Preliminary dynamic swelling studies have evidenced the occurrence of an interaction between the PHG‐UV gel and the glycoprotein. This result was confirmed by ATR FT‐IR measurements. A diffusion model using a solution of Ficks' second law was employed to determine the diffusion coefficient of water into PHG‐UV gel as a consequence of adsorption and/or interdiffusion which occur at the PHG‐UV gel/mucin solution interface. Experimental results suggest a potential use of PHG‐UV gel to prepare bioadhesive devices.
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