The ABCs of biliary cholesterol secretio
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Silvana Zanlungo; Juan Francisco Miquel; Attilio Rigotti; Flavio Nervi
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Article
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2003
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John Wiley and Sons
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English
β 62 KB
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Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans. To test this hypothesis, a P1 clone containing the human ABCG5 and ABCG8 genes was used to generate transgenic mice. The transgenes were expr