Bioactive Metabolites from the Sponge Suberea sp.

✍ Scribed by Kamel H. Shaker; Heidi Zinecker; Mohamed A. Ghani; Johannes F. Imhoff; Bernd Schneider

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 170 KB
• Volume: 7
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200900277

✦ Synopsis

Abstract

Two new brominated compounds, subereaphenol K (2) and 2‐(3,5‐dibromo‐1‐ethoxy‐4‐oxocyclohexa‐2,5‐dien‐1‐yl)acetamide (3), together with subereaphenol B (methyl 2‐(2,4‐dibromo‐3,6‐dihydroxyphenyl)acetate; 1) with a revised structure, and five dibromotyrosine‐derived metabolites, 4–8, were isolated from the sponge Suberea sp. and characterized by 1D‐ and 2D‐NMR spectroscopic and HR‐MS spectrometric data. Compounds 1, 2, 6, and 8 exhibited various weak or moderate bioactivities, including antimicrobial and cytotoxic activities. Furthermore, compounds 1 and 2 inhibited human recombinant phosphodiesterase 4 (PDE4) with IC~50~ values of 2 μM, whereas compounds 6 and 8 were less active.