Content: Cover
Contents
Preface
Acknowledgements
Chapter 1 Melt-derived Bioactive Silicate Glasses
1.1 Introduction
1.1.1 Glass --
A Versatile Biomaterial
1.1.2 Glass and Properties
1.1.3 Bioactivity of Glass
1.2 Properties Essential for Fabrication
1.2.1 Definition of Glass
1.2.2 Glass Transformation and Liquidus Temperatures
1.2.3 Crystallization
1.2.4 Crystallization of Bioactive Glasses 45S5, S53P4 and 13-93
1.2.5 Glass Stability
1.2.6 Time-Temperature-Transformation
1.2.7 Crystals in Thermal Treatment
1.2.8 Viscosity
1.3 Properties Essential in the Final Application 1.3.1 Mechanical Strength1.3.2 Dissolution Reactions
1.3.3 Dissolution Measurements
1.3.4 Dissolution in Continuously Flowing Solution
1.3.5 In vitro Studies of 45S5, S53P4 and 13-93
1.4 Conclusions and Outlook
References
Chapter 2 Bioactive Glass-ceramics: Processing, Properties and Applications
2.1 Glass-ceramic Fabrication Methods
2.2 Bioactivity
2.3 Background
2.4 Commercial Bioactive Glass-ceramics
2.5 Miscellaneous Bioactive Glass-ceramics
2.6 Magnetic Bioactive Glass-ceramics
2.7 Radiopaque Bioactive Glass-ceramics
2.8 Bioactive Glass-ceramic Coatings 2.9 Bioactive Glass-ceramic Composites2.10 Bioactive Glass-ceramic Scaffolds
2.11 Gel-derived Bioactive Glass-ceramics
2.12 Conclusions and Outlook
Acknowledgments
References
Chapter 3 Introduction to the Structure of Silicate, Phosphate and Borate Glasses
3.1 Introduction
3.2 Basics of Silicate and Phosphate Glasses
3.3 Structure and Properties of Silicate Glasses
3.3.1 Structure, Solubility and Bioactivity
3.3.2 Sol-Gel Silicate Glasses
3.4 Structure and Properties of Phosphate Glasses
3.4.1 Structure and Dissolution
3.5 Borate Glasses 3.5.1 Effect of Structure on Borate Glass Properties3.6 Mixed Glass Former Systems
3.7 Conclusions and Outlook
References
Chapter 4 Molecular Dynamics Simulations of Bioactive Glass Structure and In vitro Reactivity
4.1 Introduction
4.2 Structure
4.2.1 Simulation Methods and Aims
4.2.2 Structural Descriptors of Bioactivity and Glass Durability
4.2.3 Bioglass Nanoparticles
4.3 Dynamics and Reactivity
4.3.1 Surface and Ion-exchange Processes
4.3.2 Ion Migration
4.4 Conclusions and Outlook
Acknowledgments
References
Chapter 5 Sol-Gel Glass and Nano-Macro Porous Bioscaffolds 5.1 Introduction5.1.1 Tailored Amorphous Multi-Porous (TAMP) Bioscaffolds
5.2 Chemistry and Mechanisms of Fabrication of Sol-Gel Bioactive Glasses
5.2.1 Basic Concepts of Sol-Gel Processing
5.2.2 Modified Sol-Gel Process: Introduction of Multimodal Porosity via Multiscale Spinodal Phase Separation
5.3 Biodegradation of TAMP Bioscaffolds Fabricated by Modified Sol-Gel Method
5.4 Cell Response to TAMP Bioscaffolds
5.4.1 The Effect of Chemical Composition: Bioactive Glasses Substituted with Boron