Bioactive glass nanofiber–collagen nanocomposite as a novel bone regeneration matrix

✍ Scribed by Hae-Won Kim; Ju-Ha Song; Hyoun-Ee Kim

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 529 KB
• Volume: 79A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.30848

✦ Synopsis

Abstract

Nanoscale organized organic–inorganic nanocomposite systems have great potential in the development of biomaterials with advanced properties. Herein, we developed a novel nanocomposite biomaterial consisting of bioactive glass nanofiber (BGNF) and collagen reconstituted fibrous matrix for bone regenerative medicine. A sol–gel derived glass with a bioactive composition (58SiO~2~· 38CaO·4P~2~O~5~) was electrospun to a nanoscale fiber with an average diameter of ∼320 nm. The BGNF was subsequently hybridized with type I collagen, which is the main organic constituent of bone matrix. The BGNF and self‐assembled collagen sol were combined in aqueous solution, and then crosslinked to produce a BGNF‐collagen nanocomposite, in the form of either a thin membrane or a macroporous scaffold, by adopting appropriate processing conditions. The BGNF was observed to be distributed uniformly within the collagen reconstituted nanofibrous matrix. The nanocomposite matrices induced rapid formation of bone‐like apatite minerals on their surfaces when incubated in a simulated body fluid, exhibiting excellent bioactivity in vitro. Osteoblastic cells showed favorable growth on the BGNF‐collagen nanocomposite. In particular, the alkaline phosphatase activity of the cells on the nanocomposite was significantly higher than that on the collagen. This novel BGNF‐collagen nanocomposite is believed to have significant potential in bone regeneration and tissue engineering applications. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006