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Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors

✍ Scribed by Nina C. Lindfors; Jouni T. Heikkilä; Ilona Koski; Kimmo Mattila; Allan J. Aho

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
191 KB
Volume
90B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

In a prospective randomized study, 25 patients with benign bone tumors were surgically treated with either bioactive glass S53P4 (BG) or autogenous bone (AB) as bone graft material. X‐rays were taken preoperatively and postoperatively at 2 weeks and at 3, 8, 12, 18, 24, and 36 months. In addition, for most of the patients, CT scans were performed at the same time‐points. No infections or material‐related adverse reactions occurred in any patient. The filled cavity was replaced faster by new bone in the AB group than in the BG group (p = 0.0001). However, at 36 months, no statistical difference in cavity volume between the two groups was observed on X‐rays (p = 0.7881) or on CT scans (p = 0.9117). In the BG group at 3 years, the filled cavity appeared, however, dense on X‐rays, and glass granules on CT scans were observed. During the follow‐up period, the cortical thickness seemed to increase more in the BG group than in the AB group (p < 0.0001). © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

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