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Bio-distribution study of Reolysin® (pelareorep) through a single intravenous infusion in Sprague-Dawley rats

✍ Scribed by Chakrabarty, Romit; Tran, Hue; Boulay, Iohann; Moran, Tanya; Parenteau, Audrey; Tavcar, Robert; Bigras, Maude; Hagerman, Allison; Serl, Sarah; Thompson, Brad; Coffey, Matt

Book ID
121607931
Publisher
Springer US
Year
2013
Tongue
English
Weight
741 KB
Volume
31
Category
Article
ISSN
0167-6997

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✍ Hai-Shu Lin; Arun B. Barua; James A. Olson; Kerwin Siew Yang Low; Sui Yung Chan; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

All-trans-retinoyl-b-D-glucuronide (RAG) is an endogenous active metabolite of all-trans-retinoic acid (ATRA). In the present study, the pharmacokinetics of RAG was examined after the administration of a single intravenous does (5, 10, or 15 mmol/kg) and of multiple daily intravenous doses (5 mmol/k