✦ LIBER ✦

Binswanger's disease presenting as levodopa-responsive parkinsonism: Clinicopathologic study of three cases

✍ Scribed by Dr. M. H. Mark; J. I. Sage; A. S. Walters; R. C. Duvoisin; D. C. Miller

Book ID: 102946226
Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 516 KB
Volume: 10
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870100408

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✦ Synopsis

Abstract

We report three cases of autopsy‐proven Binswanger's disease (subcortical arteriosclerotic encephalopathy) with unusual clinical features. Two patients had supranuclear gaze disturbances, early gait dysfunction, and speech disorders suggestive of progressive supranuclear palsy. One of these patients was not demented at the time of death. The third patient had features typical of Parkinson's disease. All three patients were responsive to treatment with levodopa. The clinical spectrum of Binswanger's disease should be expanded to include levodopa‐responsive parkinsonism.

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