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Binding specificity and internalization properties of an antibody–avidin fusion protein targeting the human transferrin receptor

✍ Scribed by José A. Rodríguez; Gustavo Helguera; Tracy R. Daniels; Isabel I. Neacato; Héctor E. López-Valdés; Andrew C. Charles; Manuel L. Penichet


Book ID
113691634
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
813 KB
Volume
124
Category
Article
ISSN
0168-3659

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## Abstract ## Background The application of serotype 5 adenoviruses (Ad5) in macrophages is hampered by the absence of the endogenous coxsackie adenovirus receptor (CAR). ## Methods To overcome this limitation, we first generated a linker protein consisting of the virus‐binding domain of CAR an