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Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis

✍ Scribed by Fumi Abiko; Koji Tomoo; Atsuo Mizuno; Shigenobu Morino; Hiroaki Imataka; Toshimasa Ishida


Book ID
116294449
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
369 KB
Volume
355
Category
Article
ISSN
0006-291X

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## Abstract To clarify the higher eukaryotic initiation factor 4E (eIF4E) binding selectivity of 4E‐binding protein 2 (4E‐BP2) than of 4E‐BP1, as determined by Trp fluorescence analysis, the crystal structure of the eIF4E binding region of 4E‐BP2 in complex with m^7^GTP‐bound human eIF4E has been d