Binding of uptake blockers to the neuronal dopamine transporter: further investigation about cationic and anionic requirements

Binding of the [125I]3β-(Iodophenyl)trop

Binding of the [125I]3β-(Iodophenyl)tropan-2β-carboxylic acid isopropyl ester to the dopamine transporter at a physiologically relevant temperature: Mutually exclusive binding and different ionic requirements for various uptake blockers and substrates

✍ Nian-Hang Chen; You-Lin Wang; Maarten E.A. Reith 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

The present study describes the binding of cocaine analog [ 125 I]3b-(iodophenyl)tropan-2b-carboxylic acid isopropyl ester ([ 125 I]RTI-121), a highly selective ligand for the dopamine transporter (DAT), to rat striatal synaptosomal membranes at 37°C. Saturation analysis of [ 125 I]RTI-121 binding r