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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

✍ Scribed by Michels, Annemieke A; Fraldi, Alessandro; Li, Qintong; Adamson, Todd E; Bonnet, François; Nguyen, Van Trung; Sedore, Stanley C; Price, Jason P; Price, David H; Lania, Luigi

Book ID: 110030668
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 286 KB
Volume: 23
Category: Article
ISSN: 0261-4189
DOI: 10.1038/sj.emboj.7600275

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## Abstract P‐TEFb functions to induce the elongation step of RNA polymerase II transcription by phosphorylating the carboxyl‐terminal domain of the largest subunit of RNA polymerase II. Core P‐TEFb is comprised of Cdk9 and a cyclin regulatory subunit, with Cyclin T1 being the predominant Cdk9‐asso