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Binding of Natively Unfolded HIF-1α ODD Domain to p53

✍ Scribed by Nuria Sánchez-Puig; Dmitry B. Veprintsev; Alan R. Fersht


Book ID
116753719
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
402 KB
Volume
17
Category
Article
ISSN
1097-2765

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## Abstract Tumor hypoxia has been known to be associated with resistance to radiation and chemotherapy (CRT). Hypoxia‐inducible factor‐1α (HIF‐1α), a transcription factor induced by hypoxic condition, plays a major role in the pleiotropic response observed under hypoxic conditions. It encodes prot