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Binding of ligands to a one-dimensional heterogeneous lattice. I. General model for the calculation of binding isotherms by a Monte Carlo approach

✍ Scribed by Jean Sturm

Publisher
Wiley (John Wiley & Sons)
Year
1981
Tongue
English
Weight
534 KB
Volume
20
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

A Monte Carlo method is presented to calculate equilibria for the binding of ligands to one‐dimensional heteropolymers. Equivalency with other methods suitable for particular cases was verified (i.e., matrix and combinatorial methods). The principal interest of this Monte Carlo method is in its facility for adaptation to any physically conceivable binding model and that it gives access to the parameters accounting for partial binding to each different type of site. General properties of binding isotherms with excluded‐site effects and relations between partial binding ratios and partial free site ratios are discussed. An effective calculation is presented for illustration of the method.

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