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Binding of insulin-like growth factor-I by glomerular endothelial and epithelial cells: Further evidence for IGF-I action in the renal glomerulus

✍ Scribed by Francesco G. Conti; Sharon J. Elliot; Liliane J. Striker; Gary E. Striker


Book ID
115762321
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
573 KB
Volume
163
Category
Article
ISSN
0006-291X

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IGF-I is mitogenic for the bovine mammary epithelial cell line MAC-T. In addition, IGF-I specifically upregulates IGFBP-3 synthesis in these cells. To investigate this effect on cell growth and IGF-I responsiveness, cell lines were developed that constitutively express IGFBP-3. MAC-T cells transfect