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Binding of glycoprotein IIIa-derived peptide 217–231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complex

✍ Scribed by Jacquelynn J. Cook; Maciej Trybulec; Elizabeth C. Lasz; Shabbir Khan; Stefan Niewiarowski


Book ID
113268810
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
940 KB
Volume
1119
Category
Article
ISSN
0167-4838

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Arg-Gly-Asp (RGD)-containing peptides and the peptide unique to fibrinogen in the C-terminal domain of the gamma chain are important for fibrinogen binding to platelet membrane glycoprotein (GP) II b/III a. We synthesized a unique hybrid peptide of YRGDSPLGGAKQAGDV encompassing the RGD sequence (RGD