Binding of Escherichia coli heat-stable enterotoxin and rise of cyclic GMP in COLO 205 human colonic carcinoma cells
โ Scribed by Jayanta Bhattacharya; Alok Ghosh Chaudhuri; Ajoy K. Sinha; Ajoy K. Samanta; Manoj K. Chakrabarti
- Book ID
- 117518368
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 682 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0378-1097
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## Abstract It was reported earlier that __Escherichia coli__ heat stable enterotoxin (STa), a major causative agent of secretory diarrhea, can also inhibit the proliferation of colon carcinoma cells with the involvement of cGMP mediated calcium influx. In the present study it is shown that __E. co
Stable toxin (ST) peptides are the causative agents for a severe form of watery diarrhea. These peptides bind to a membrane-associated form of guanylyl cyclase, guanylyl cyclase C. The result is an accumulation of cyclic guanosine monophosphate (cGMP) in the intestinal cell, regulating protein kinas