Binding of dissimilar ligand molecules to an interacting acceptor: A model for the action of effectors
β Scribed by L.W. Nichol; K. O'Dea; P.A. Baghurst
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- English
- Weight
- 468 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-5193
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π SIMILAR VOLUMES
## Abstract The theoretical study of the cooperative binding of a small ligand to a linear homopolymer is extended to systems in which two different complexes can form. The binding isotherms are derived under the assumption that the cooperative interactions exist only between molecules belonging to
Pleckstrin homology (PH) domains have been proven to bind phosphoinositides (PI) and inositolphosphates (IP). On the other hand, a binding of PH domains to proteins is still a matter of debate. The goal of this work was to identify potential PH domain protein target sites and to build a model for PH