Binding of cosalane—a novel highly lipophilic anti-HIV agent—to albumin and glycoprotein

Transport of cosalane—a highly lipophili

Transport of cosalane—a highly lipophilic novel anti-HIV agent—across Caco-2 cell monolayers

✍ Dhananjay Pal; Chandrasekhar Udata; Ashim K. Mitra 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 1 views

Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral bioavailability of this highly lipophilic compound is extremely poor (<1%). Also, cosalane accumulates in high concentration in the liver after intravenous administration, with c