Binding of cadmium on metallothionein in man: an analysis of a fatal poisoning by cadmium iodide

✍ Scribed by Justyna M. Wiśniewska-Knypl; Janina Jabłońska; Z. Myślak

• Publisher: Springer-Verlag
• Year: 1972
• Tongue: English
• Weight: 489 KB
• Volume: 28
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00349627

✦ Synopsis

This study presents data on the organ distribution of cadmium, and Cd-protein complexes in the body of a man fatally poisoned with CdJ~, after an oral dose of about 5 g.

The levels of cadmium in different tissues were (in izg per g fr. wt.): liver and kidney cortex about 80, kidney medulla, heart and testes 8.9-10.0, bile 1.9, brain 0.5 and blood 1.1.

Almost all cadmium detected in the organism was bound to a low molecular weight protein, tentatively identified as metallothionein.

Total amount of 18 nag cadmium was excreted in urine within 6 days of hospitalization, most likely due to Ca-EDTA treatment.

The data are suggestive that cadmium induced biosynthesis of metallothionein in the subject.