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Binding of brevetoxins and ciguatoxin to the voltage-sensitive sodium channel and conformational analysis of brevetoxin B

โœ Scribed by Robert E. Gawley; Kathleen S. Rein; Masao Kinoshita; Daniel G. Baden


Book ID
116073052
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
379 KB
Volume
30
Category
Article
ISSN
0041-0101

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Is the A-ring lactone of brevetoxin PbTX
โœ Professor Daniel G. Baden; Kathleen S. Rein; Robert E. Gawley; Gerhard Jeglitsch ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 841 KB

Brevetoxin PbTx-3 and non-toxic derivative 4 were investigated for their abilities to bind to the specific brevetoxin receptor site on rat brain synaptosomes and to modulate the normal function of voltage-gated sodium channels as determined by patch clamping of cultured neurons. Compounds 4 and 5 ar