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Binding mode of ecdysone agonists to the receptor: comparative modeling and docking studies

✍ Scribed by Atsushi Kasuya; Yoshihiro Sawada; Yoshihisa Tsukamoto; Keiji Tanaka; Tetsuya Toya; Mikio Yanagi


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
580 KB
Volume
9
Category
Article
ISSN
1610-2940

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A recent study reported a model of the human A(1) adenosine receptor and its agonist binding site, proposing two putative binding modes in the same binding site for the natural agonist, adenosine. The present work investigates the flexibility of this binding site by exhaustive exploration with the n