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Binding kinetics and antiplatelet activities of picotamide, a thromboxane A2 receptor antagonist

✍ Scribed by Pietro Amedeo Modesti; Ilaria Cecioni; Andrea Colella; Alessandro Costoli; Rita Paniccia; Gian Gastone Neri Serneri

Book ID
117959969
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
981 KB
Volume
112
Category
Article
ISSN
0007-1188

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β€œIn vitro” and β€œex vivo” effects of pico
β€œIn vitro” and β€œex vivo” effects of picotamide, a combined thromboxane A2-synthase inhibitor and -receptor antagonist, on human platelets
✍ M. Berrettini; M. Cunto; P. Parise; S. Grasselli; G. G. Nenci πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 599 KB

Picotamide (G 137), a new non prostanoid inhibitor of in vitro arachidonic acid induced platelet aggregation, has been further characterized in in vitro and ex vivo studies. When whole blood was activated with collagen in the presence of picotamide 5 x 10(-4) M, thromboxane B2 production was decreas