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Binding and internalization of the melanocyte stimulating hormone receptor ligand [Nle4, d-Phe7]α-MSH in B16 melanoma cells

✍ Scribed by Wysun Wong; Rodney F. Minchin


Book ID
117756246
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
966 KB
Volume
28
Category
Article
ISSN
1357-2725

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✍ L. C. Panasci; A. McQuillan; M. Kaufman 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 731 KB

The alpha-MSH (alpha-melanocyte-stimulating hormone) agonist, Ac-[Nle4, D-Phe7]alpha-MSH4-11NH2 (hereafter called ND4-11 alpha-MSH), is at least 10-fold more potent than alpha-MSH as a stimulus of tyrosinase activity in F1 variant cells of B16 melanoma. The binding to these cells during an incubatio