Binding and internalization of Helicobacter pylori VacA via cellular lipid rafts in epithelial cells
β Scribed by Chun-Hsien Kuo; Wen-Ching Wang
- Book ID
- 117053583
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 306 KB
- Volume
- 303
- Category
- Article
- ISSN
- 0006-291X
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## Abstract In this study, we have evaluated the effects on cell cycle regulation of VacA alone and in combination with other two __Helicobacter pylori__ proteins, cytotoxinβassociated protein (CagA) and HspB, using the human gastric epithelial cells (AGS). Our results indicate that VacA alone was
## Abstract Infection with CagAβpositive __Helicobacter pylori__ is the strongest risk factor for gastric carcinoma. Upon delivery into gastric epithelial cells, CagA disturbs cellular functions by physically interacting with and deregulating intracellular signaling molecules via both tyrosine phos