The capacity of caffeine to induce sister chromatid exchanges (SCEs) in different cell cycle stages and the proliferation kinetics were studied. Continuous treatment with this xanthine during the whole second cycle significantly increased the baseline SCE frequency. Pulse-treatment experiments showe
โฆ LIBER โฆ
Bimodal induction of sister-chromatid exchanges by luminol, an inhibitor of poly(ADP-ribose) synthetase, during the S-phase of the cell cycle
โ Scribed by Takaji Ikushima
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 807 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0009-5915
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To investigate the origin of sister chromatid exchanges (SCEs) induced by inhibitors of DNA synthesis, V79/AP4 Chinese hamster cells were treated with aphidicolin, 1-beta-D-arabinofuranosylcytosine, and thymidine. At the end of the treatments we determined both the distribution of the cells in the v