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Bimodal Concentration-Dependent Effect of Thrombin on Endothelial Cell Proliferation and Growth Factor Release in Culture

✍ Scribed by Valeria Borrelli; Antonio V. Sterpetti; Pierpaolo Coluccia; Bruto Randone; Antonino Cavallaro; Luciana Santoro D'Angelo; Alessandra Cucina

Book ID: 115636468
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 183 KB
Volume: 100
Category: Article
ISSN: 0022-4804
DOI: 10.1006/jsre.2001.6231

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## Abstract Human neonatal skin fibroblasts plated sparsely in MCDB 105 traversed a complete cell cycle in the absense of serum or serum‐derived proteins. Addition of pure PDGF did not significantly increase entrance into S phase as revealed by ^3^H‐thymidine labeling index or clonal growth on pall