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Bilirubin-UDP-glucuronosyltransferase: Genetic defect of the hyperbilirubinemic gunn rat, a model of crigler-najjar syndrome type I

✍ Scribed by Hiroshi Sato; Sachiko Aono; Olivier Darios; Jean Michel Heard; Osamu Koiwai


Book ID
112212669
Publisher
AlphaMed Press
Year
1994
Tongue
English
Weight
631 KB
Volume
12
Category
Article
ISSN
1066-5099

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The presence of a microsomal UDP-glucuro
✍ Gerard B. Odell; Julio O. Cukier; Glenn R. Gourley πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 962 KB

The infusion of a closely related derivative of bilirubin, its dimethyl diester (DME), into jaundiced (jj) Gunn rats was associated with biliary excretion of mono-and diglucuronides of bilirubin. In uitro incubation of DME with liver microsomes from jj rats demonstrated sequential demethylation and