Biliary secretion of bile acids and lipids in primary sclerosing cholangitis.Influence of cholestasis and effect of ursodeoxycholic acid treatment
โ Scribed by Adolf Stiehl; Gerda Rudolph; Peter Sauer; Lorenz Theilmann
- Book ID
- 118567251
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 650 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0168-8278
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, doubleblind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed
Ursodeoxycholic acid (UDCA) has beneficial effects in cholestatic liver diseases. In primary sclerosing cholangitis (PSC), there is evidence that high doses (ุ20 mg/kg) of UDCA may be more effective than average doses. Biliary enrichment of UDCA at such high doses may represent the decisive factor f
In five patients with radiolucent gallstones, the effect of ursodeoxycholic acid (Urso) in doses of 250,500, 750, 1,000, and 1,250 mg per day on biliary lipid and bile acid composition was studied. Biliary cholesterol decreased from 8.8 f 0.8 mole% to 4.4 f 0.2 mole% at 500 mg Urso per day (7.1 mg p