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Biliary Excretion of Ximelagatran and Its Metabolites and the Influence of Erythromycin Following Intraintestinal Administration to Healthy Volunteers

✍ Scribed by Matsson, Elin M.; Eriksson, Ulf G.; Knutson, Lars; Hoffmann, Kurt-Jürgen; Logren, Ulrika; Fridblom, Patrik; Petri, Niclas; Lennernäs, Hans


Book ID
120795943
Publisher
Sage Publications
Year
2011
Tongue
English
Weight
404 KB
Volume
51
Category
Article
ISSN
0091-2700

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## Abstract Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the admini