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Bile Salt Hydrophobicity Modulates Subselection of Biliary Lecithin Species in Rats Depleted of Bile Salt Pool

✍ Scribed by Hiroaki Miyake; Susumu Tazuma; Goro Kajiyama


Book ID
110379006
Publisher
Springer US
Year
1998
Tongue
English
Weight
177 KB
Volume
43
Category
Article
ISSN
0163-2116

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Intraduodenal infusion of hydrophobic bile salts to bile-fistula rats leads within hours to severe hepatocellular necrosis and cholestasis; simultaneous administration of conjugates of ursodeoxycholate, either intraduodenally or intravenously, reduces or prevents liver injury. To evaluate the short-