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Bile concentration promotes nucleation of cholesterol monohydrate crystals by increasing the cholesterol concentration in the vesicles

✍ Scribed by K. J. VAN ERPECUM; M. F. J. STOLK; A. M. W. C. VAN DEN BROEK; W. RENOOIJβ; B. J. M. VAN DE HEIJNING; G. P. VAN BERGE HENEGOUWEN


Book ID
114727218
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
639 KB
Volume
23
Category
Article
ISSN
0014-2972

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📜 SIMILAR VOLUMES


Bile concentration is a key factor for n
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## I We investigated whether bile concentration influenced cholesterol saturation index or nucleation time of cholesterol monohydrate crystals in a large number of gallbladder bile samples. Pigment stone patients never had cholesterol crystals in their fresh biles, and nucleation time was always l

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3-hydroxy,3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors reduce biliary cholesterol saturation index (CSI) in duodenal bile in hypercholesterolemic patients and might be useful for gallstone dissolution. However, preliminary data suggest that these drugs are not effective in this respect