Bile acids. LXIV. Synthesis of 5α-cholestane-3α,7α,25-triol and esters of new 5α-bile acids
✍ Scribed by S.V. Hiremath; William H. Elliott
- Book ID
- 118978859
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 622 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0039-128X
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📜 SIMILAR VOLUMES
## Abstract Tritiation of 7‐oxo‐5‐cholestene‐3β,26‐diol diacetate afforded a mixture of [5α,6α‐^3^H~2~] products which were reduced with lithium aluminum hydride to provide a mixture of [5α,6α‐^3^H~2~]‐3β, (7α and 7β), 26‐triols an 3β, 26‐diol. Oxidation with Jones reagent provided 3,7‐dioxo and 3‐
## ABSTRAm A facile and regiocontrolled procedure for the preparation of S~-cholestane-3a,7c,l2~,25-tetrol-3-O-fi-o-glucuronide and its corresponding C-26 analogue is described. The method involves direct coupling of bile alcohols, namely, 5/3-cholestane-3rY,7~,12a,25-tetrol and 24-nor-Sp-cholesta