Bile acids in regulation of intestinal physiology
β Scribed by Niamh Keating; Stephen J. Keely
- Book ID
- 107538516
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 356 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1522-8037
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Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7a-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile ac
Ileal expression of the apical sodium-dependent bile acid transporter (ASBT) in the rat is unaffected by bile salts, yet in the mouse it is under negative-feedback regulation. The bile acid responsiveness of human ASBT is unknown. The human ASBT promoter linked to a luciferase reporter was studied i
ous Saudi Arabian families. 10 A rat SPGP cDNA was used to isolate a human orthologue of SPGP. The human SPGP and the FIC2 locus were found to lie in an 870-kb yeast artificial chromosome insert. PFIC patients in whom the pattern of marker inheritance was consistent with linkage to chromosome 2q24 w
Bile acid synthesis is thought to be regulated by a negative feedback mechanism which is presumably dependent upon the flux of bile acids in the enterohepatic circulation. To characterize further the role of bile acids in regulation of bile acid synthesis, we have administered pure taurine or glycin