Feedback regulation of bile acid synthesis by its end products was studied in cultured hepatocytes of young weaned pigs. We previously showed that conversion of exogenous ["Cl cholesterol into bile acids was suppressed by addition of bile acids to the culture medium. In the present study, the effec
β¦ LIBER β¦
Bile acid metabolism in cirrhosiso. VII. Evidence for defective feedback control of bile acid synthesis
β Scribed by Z. Reno Vlahcevic; Marc Goldman; Charles C. Schwartz; Jan Gustafsson; Leon Swell
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 560 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0270-9139
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Primary human hepatocytes were used to elucidate the effect of individual bile acids on bile acid formation in human liver. Hepatocytes were treated with free as well as glycine-conjugated bile acids. Bile acid formation and messenger RNA (mRNA) levels of key enzymes and the nuclear receptor short h