Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: Differing effects of cyclosporine and FK 506
✍ Scribed by Timothy M. McCashland; Jeremiah P. Donovan; Andree Amelsberg; Steven S. Rossi; Alan F. Hofmann; Byers W. Shaw Jr.; Eamonn M. M. Quigley
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 953 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
Bile acid metabolism and biliary secretion were characterized in the b t 2 wk after orthotopic liver traasplantation in 16 patients receiving cyclosporine and in five patients receiving FK 606. Analyses were performed on hepatic bile obtained by T-tube d r a values obtained were compared with literature values for bile samples obtained in patients who had w m n e cholecystectomy. Biliary bile acid output, which is equivalent to bile acid biosynthesis from cholesterol, was low (mean 2 S.E.M.) and increwed with time: day 1, 0.60 * 0.1 mmoUday; day 3, 0.8 f 0.1 mmol/dax and day 6, 1.6 2 0.5 mmovday. Chenodeoxycholic acid biosynthesis, as percent of total bile acid biosynthesis, was abnormally low in